Granuloma | Anatomy2Medicine
Granuloma Inflamation



  • with T lymphocytes is involved.
        • Poorly digestible antigen is presented by macrophages to CD4+ lymphocytes
        • Interaction with the antigen-specific T-cell receptor of these cells triggers the release of cytokines (especially interferon-γ),
        • interferon-γ mediate the transformation of monocytes aGranulomatous inflammation
  • Granulomas,
            • nodular collections of specialized macrophages referred to as epithelioid cells. (MCQ)
            • Granulomas are usually surrounded by a rim of lymphocytes. (MCQ)
        • Activation of macrophages by interactionsnd macrophages to epithelioid cells and giant cells. (MCQ)
      • Caseous necrosis
        • Characteristic of tuberculosis(MCQ)
        • result from the killing of mycobacteria-laden macrophages by T lymphocytes.
        • Noncaseating pulmonary granulomatous disease is caused most often by sarcoidosis. (MCQ)
        • presence of multinucleated giant cells derived from macrophages is also characteristic. (MCQ)
  • Langhans giant cell
          • It has nuclei arranged in a horseshoe-shaped pattern about the periphery of the cell
          • It is particularly characteristic of, but not specific for, the granulomatous inflammation of tuberculosis
  • Foreign body giant cell has scattered nuclei
      • Granulomatous inflammation is the characteristic form of inflammation associated with (MCQ)
  • Mycobacterium tuberculosis and M. leprae
  • Blastomyces dermatitidis
  • Histoplasma capsulatum
        • Coccidioides immitis,
  • Treponema pallidum
      • The bacterium of cat-scratch disease
      • Foreign bodies
      • Sarcoidosis